Juniper Publishers Journal of Cell Science

Response to Eribulin in a Difficult-To-Treat Triple NegativeBreast Cancer Patient by Raul Marquez Vazquez in Juniper Publishers in InternationalJournal of Cell Science & Molecular Biology In this paper, we report our experience with eribulinmesylate in a locally advanced triple negative breast cancer (BC) patient who was treated with antracyclines and taxanes, and became metastatic. After one refractory line with Capecitabine and Bevacizumab, there was response to Eribulin. No unexpected acute toxicity was observed. https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555559.php For more Open access journals please click on JuniperPublishers :  https://juniperpublishers.com/ For more articles please click on International Journal ofCell Science & Molecular Biology : https://juniperpublishers.com/ijcsmb/index.php

Lipomatosis in a Developing Communitys by Wilson IB Onuigbo in Juniper Publishers in International Journal of Cell Science & MolecularBiology A Birmingham (UK) group postulated that a histopathology data pool opens the gate to epidemiologic analysis. Such a pool came into existence among an Ethnic Group called the Ibos or Igbos in South-eastern Nigeria. Personal analysis of it from the 1970s to 2000 yielded 22 examples. Among them, one case was familial. Most occurred in males, the M/F ratio being 19/3. None was detected outside the skin. Most cases were diagnosed at the Cosmopolitan Enugu (12 cases), while the next ranking town was Afikpo (4 cases), this being a missionary outpost in the hinterlands. Concerning age, most males were in the 21-40 age groups, whereas the females were in the 41-61 older age bracket. Hardly any was painful. With 4 cases submitted by a specialist in Dermatology, most were sent by other single practitioners. https://juniperpublishe

Prion diseases are transmitted by the protein agent that can transfer its distinct misfolded structure to its normal counterparts and form insoluble aggregates in the nervous system. Recent findings led to the emergence of the prion paradigm of the protein agents that underlie neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). This review will discuss current knowledge concerning both human prion diseases and prion-like transmission properties related to neurodegenerative diseases. https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555557.php For more Open access journals please click on   https://juniperpublishers.com/ For more articles please click on  https://juniperpublishers.com/ijcsmb/index.php

Since Dolly cloning by Ian wilmut, Scientists have raised a heated debate in various means of communication, the issue of human being cloning. Since that time the researchers tried in their laboratories to clone human for about two decades without successful results. Not only this, but one of the south Korean researchers, on Dec. 24, 1998 falsely claimed that he had successful human being cloning, which later on according to a report released by Seoul National University panel investigating his work, revealed that Dr. Hwang Woo-Suk who claimed to have cloned human cells was having a fallacious report and fabricated data for all of that research and he convicted for embezzlement and false claim. https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555556.php For more Open access journals please click on   https://juniperpublishers.com/ For more articles please click on  https://juniperpublishers.com/ijcsmb/

Regarding translational research on lung cancer, a recent report came from China. In the present paper from Nigeria, necrosis was noted to occur when cancer cells being transported within the thoracic duct were comingled with red cells. It was hypothesized that the retrieval of such rich natural pabulum in addition to the replication of it in translational laboratories will conduce to cancer cure. https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555555.php For more Open access journals please click on   https://juniperpublishers.com/ For more articles please click on  https://juniperpublishers.com/ijcsmb/

The CRISPR/ Cas9 machinery, which is known to provide adaptive immunity to bacteria and archeae, has been proven an efficient tool for genome editing in a wide range of organisms. It is an RNA-guided DNA endonuclease that introduces double-stranded breaks in the target DNA. This compact machinery has been adapted and is being widely used for precise editing and modification of the genome [1]. This review focuses on genome editing using the CRISPR/ Cas9 system for correction of genetic diseases. Here, we review examples from literature where the CRISPR/ Cas9 system has been used for the correction of Duchenne Muscular Dystrophy (DMD), cataract caused due to mutations in the Crygc gene, cystic fibrosis, and sickle cell disease. https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555554.php For more Open access journals please click on  https://juniperpublishers.com/ For more articles please click on  https://juniperpublishers.com/ijcsmb/index.php

Cadmium is an established toxic metal with its ability to accumulate in blood, liver and kidney. Cadmium is chemically related to zinc and found wherever zinc occurs in nature. It is emitted to air and water by mines, metal foundries and industries using Cadmium in alkaline accumulators, alloys, paints and plastics. Cadmium is known to alter the tissue distribution of the essential trace metals like Zn, Cu and Fe this effect has been shown to be associated with many of the toxic effects of cadmium like anemia and anosmia. Protein malnutrition enhances the susceptibility to cadmium intoxication which affects metabolism of essential trace elements; Zn, Fe and Cu were studied, in normal and protein under-nourished rats. Estimation of metals was done routinely in samples of urine and tissue (brain, liver, kidney and blood) in rats of dietary groups, 21% and 8%, after 120 days of Cd exposure, 50 ppm, through drinking water. Significant aberrations in levels of the essenti

The far famed, weighty work of Willis on metastasis contains two statements on melanuria on the basis of the urinary bladder and even the liver. Therefore, this paper considers further evidences based on collating sufficient materials from The Transactions of the Pathological Society of London. The findings included wide ranging discussion of melanuria by the old masters themselves as well as at present Read more please click on:   Full text For more Open access journals please click on  Juniper Publishers    For more articles please click on  Journal of Cell Science & Molecular Biology

Exosomes are small mobile endocytic vesicles (30-120nm), shredded by every cell to conduct trafficking of cell generated cargo. They are found in almost all body fluids (blood, csf, saliva, urine). These include proteins, lipids, DNA, mi(cro)RNAs etc. In multicellular organisms, they are packaged into numerous vesicles mainly in exosomes to conduct their transport for various cellular activities which can be exploited clinically. Presently the survival of renal allograft is monitored by mostly invasive methods (tissue biopsy, Creatinine, GFR) where curving the injury is quite difficult. Hence potency of molecular markers like proteins and then circulating miRNAs came to picture for early detection of renal injury (Acute Kidney Injury-AKI and Chronic Kidney Disease-CKD). However, due to lack of specificity of circulating miRNAs lose their feasibility and the discovery of these exosomal cargos in cellular communication has become an efficient tool for treatment of variou

International Journal of Cell Science & Molecular Biology is an Open Access, peer-reviewed, international journal with a wide range of fields within the discipline creates a platform for the authors to publish their comprehensive and most reliable source of information on the discoveries and current developments in the field of cell science & molecular biology. Cell biology is a branch of biology that studies cells – their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. Molecular biology the branch of biology that deals with the structure and function of the macromolecules (e.g. proteins and nucleic acids) essential to life. Molecular and cellular biology are interrelated, since most of the properties and functions of a cell can be described at the molecular level. IJCSMB concerns about the various system of a cell and interaction among various bi