Biomolecular Interaction and Photohemolytic Effect of Gold Nanoparticles- Juniper Publishers


The interaction between colloidal gold nano particles with bovine serum albumin, hemoglobin and Deoxy Ribo Nucleic acid were studied by spectroscopy. The conjugation of proteins with NPs not only affords stabilization of the system but, more importantly, also introduces biocompatible functionalities into nano particles for further biological interactions. The surface modifications of gold nano particles to provide stable bimolecular functionalized NPs in biomedical applications have been reported. Next, photo hemolytic activity of gold nanoparticles and light photons in hematocrit were studied. Photo induced hemolysis is a colloidal-osmotic process due to loss of selective permeability of the photo damaged membrane leads to indiscriminate entrance of solute molecules, swelling and eventual membrane rupture. 30 nm gold nanoparticles were synthesized by reduction technique using trisodium citrate and the size was confirmed by Transmission electron Microscopy and UV-Visible absorption spectroscopy.

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