Molecular Imaging with Chemokine Receptor4 (Cxcr4) In Breast Cancer- Juniper Publishers

In this study, CXCR4 siRNA labeled with 99mTc was used in gene imaging of nude mice for the breast carcinoma. Small interference RNA (siRNA) targeting human CXCR4 was radiolabeled by using the bifunctional chelator HYNIC. Negative control siRNA were synthesized by siRNA targeted to CXCR4 mRNA and radiolabeled by 99mTc with the bifunctional chelator HYNIC. Animal models of nude mice bearing human breast cancer MDA-MB-231 were established, divided them into three groups, 10 mice in each group. 7.4MBq of 99mTcO4-, 99mTc- HYNIC(siRNA) and 99mTc-HYNIC(-siRNA) were separately injected through tail vein to the three groups. Images of these animal modelswere acquired with SPECT, the ratio of T/M was calculated by region of interest (ROI)

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