The Role of Heme Oxygenase 1 in Drug-Resistance in Hematoloigcal Malignancies-Juniper Publishers
Heme oxygenase-1(HO-1) is well-known as its strong capacity of oxidative stress decreasing, inflammatory response attenuating and anti-apoptosis. Recent reports indicate the promotive efficacy of HO-1 on drug-insensitivity in hematological malignancies. Herein, we conduct this article to review the anti-apoptotic activities and the mechanism involved in chemo-resistance induced by abnormal expression of HO-1. In conclusion, these research progresses provide an insight into knowing properties of HO-1 and disclose a new strategy to reversing drug-resistance in hematological malignancies. To read more please click on: Full text For more Open access journals please click on Juniper Publishers For more articles please click on Journal of Cell Science & Molecular Biology