The Role of Heme Oxygenase 1 in Drug-Resistance in Hematoloigcal Malignancies-Juniper Publishers

Heme oxygenase-1(HO-1) is well-known as its strong capacity of oxidative stress decreasing, inflammatory response attenuating and anti-apoptosis. Recent reports indicate the promotive efficacy of HO-1 on drug-insensitivity in hematological malignancies. Herein, we conduct this article to review the anti-apoptotic activities and the mechanism involved in chemo-resistance induced by abnormal expression of HO-1. In conclusion, these research progresses provide an insight into knowing properties of HO-1 and disclose a new strategy to reversing drug-resistance in hematological malignancies.


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