The Role of Heme Oxygenase 1 in Drug-Resistance in Hematoloigcal Malignancies-Juniper Publishers

Heme oxygenase-1(HO-1) is well-known as its strong capacity of oxidative stress decreasing, inflammatory response attenuating and anti-apoptosis. Recent reports indicate the promotive efficacy of HO-1 on drug-insensitivity in hematological malignancies. Herein, we conduct this article to review the anti-apoptotic activities and the mechanism involved in chemo-resistance induced by abnormal expression of HO-1. In conclusion, these research progresses provide an insight into knowing properties of HO-1 and disclose a new strategy to reversing drug-resistance in hematological malignancies.


To read more please click on: Full text
For more Open access journals please click on Juniper Publishers  
For more articles please click on Journal of Cell Science & Molecular Biology

Comments

Post a Comment

Popular posts from this blog

Hypothesis Nature has provided the two Subsets required for Translational Lung Cancer Research-Juniper Publishers

Image
Regarding translational research on lung cancer, a recent report came from China. In the present paper from Nigeria, necrosis was noted to occur when cancer cells being transported within the thoracic duct were comingled with red cells. It was hypothesized that the retrieval of such rich natural pabulum in addition to the replication of it in translational laboratories will conduce to cancer cure. https://juniperpublishers.com/ijcsmb/IJCSMB.MS.ID.555555.php For more Open access journals please click on   https://juniperpublishers.com/ For more articles please click on  https://juniperpublishers.com/ijcsmb/
Read more

Lipomatosis in a Developing Communitys-Juniper Publishers

Image
Lipomatosis in a Developing Communitys by Wilson IB Onuigbo in Juniper Publishers in International Journal of Cell Science & MolecularBiology A Birmingham (UK) group postulated that a histopathology data pool opens the gate to epidemiologic analysis. Such a pool came into existence among an Ethnic Group called the Ibos or Igbos in South-eastern Nigeria. Personal analysis of it from the 1970s to 2000 yielded 22 examples. Among them, one case was familial. Most occurred in males, the M/F ratio being 19/3. None was detected outside the skin. Most cases were diagnosed at the Cosmopolitan Enugu (12 cases), while the next ranking town was Afikpo (4 cases), this being a missionary outpost in the hinterlands. Concerning age, most males were in the 21-40 age groups, whereas the females were in the 41-61 older age bracket. Hardly any was painful. With 4 cases submitted by a specialist in Dermatology, most were sent by other single practitioners. https://juniperpublishe
Read more

Nasopharyngeal Lymphoma in a developing Community- juniper Publishers

Image
Juniper Publishers- Journal of cell Science Abstract The nasopharyngeal lymphoma has been reported from countries as far apart as China, Hong Kong, India, Korea, Morocco, Tunisia, and USA. Therefore, this report comes from Nigeria with special reference to the Ibo ethnic group. It was found that mostly young patients of either sex were involved. Follow-up data are not available. Keywords: Nasopharynx; Lymphoma; Age; Nigeria; Ibos Introduction Squamous cell carcinoma is defined as “a malignant epithelial neoplasm exhibiting squamous differentiation as characterized by the formation of keratin and/or the presence of intercellular bridges” [1]. This was illustrated in a case report from India [1] as well as from Saudi Arabia [2] and from the UK [3]. Therefore, this paper presents a series from the Ibo ethnic group’s developing community [4], this being done on account of the author’s headship of a histopathology data pool such as the one fostered by a Birmingham (UK) group [
Read more