Juniper Publishers: New Insight into the Treatment of Primary Myelofib...

Juniper Publishers: New Insight into the Treatment of Primary Myelofib...: Cancer Therapy

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Dedifferentiated Chondrosarcoma of the Larynx: A Case Report and Review of the Literature- Juniper Publishers

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Juniper Publishers- Journal of cell Science Abstract Background: Laryngeal chondrosarcomas are rare, slow-growing, cartilaginous tumors. Dedifferentiated chondrosarcomas, a rare entity of chondrosarcoma, are more aggressive and associated with a more ominous prognosis. Definite diagnosis can be established by incisional biopsy and histopathologic examination. Histopathologic examination reveals a cartilaginous tumor with a malignant spindle cell component. Definitive reatment of dedifferentiated chondrosarcomas of the larynx is total laryngectomy. There have been 14 case reports of laryngeal dedifferentiated chondrosarcoma reported since 1988. The average life expectancy reported is 6 months, and a 5-year survival rate of 10.5%. Case presentation: We present a case of dedifferentiated chondrosarcoma arising in the cricoids cartilage of a male patient, who presented with 3-week history of dyspnea, stridor, dysphonia and intermittent aphonia. As a result, he un...
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Autoimmune Diseases and Inflammatory Disorders of Unknown Etiology; Contemplating Causation and Implication in Public Health Protection- Juniper Publishers

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Juniper Publishers- Journal of cell Science Abstract Due to their multi factorial causation, the investigation of the etiology of autoimmune and inflammatory disorders constitutes a challenge that seems to exceed greatly that which was faced by the pioneers of the previous centuries, in connection with microbial diseases. Genetic factors, microbial pathogens, the alteration of the normal microbial flora and/or of the micro biome have been implicated to the etiology of the specific category of diseases but their interaction is so complex that the distinction of the causal from those that are incidental becomes extremely difficult. This issue is further complicated by food additives that are nowadays widely used and could have a contributing role to the pathogenesis of disorders associated with immune dysregulation. In this respect, it is perhaps critical that administrative authorities involved in public health protection revised their licensing strategy from decidi...
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